Oligoclonal bands and antibody responses in multiple sclerosis. Additional information regarding LOINC codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf. Early Differential Diagnosis of Multiple Sclerosis Using a New - JAMA Lahuerta JJ, Jimenez-Ubieto A, Paiva B, et al. Oligoclonal bands (OCB); multiple sclerosis; neurodegenerative disorders; peripheral neuropathy. Oligoclonal Banding, Serum Useful For Diagnosis of multiple sclerosis; especially useful in patients with equivocal clinical presentation and radiological findings Determining number of serum oligoclonal bands in order to calculate the number of cerebrospinal fluid-specific bands present Method Name Only orderable as part of a profile. 2010. None found; four or more CSF-specific bands have been shown to be most consistent with MS. The specimen can be serum, urine, or CSF. eCollection 2017. 8600 Rockville Pike Ferraro D, Trovati A, Bedin R, Natali P, Franciotta D, Santangelo M, Camera V, Vitetta F, Varani M, Trenti T, Gastaldi M, De Biasi S, Nasi M, Pinti M, Meletti S, Sola P. Eur J Neurol. Hematology: Basic Principles and Practice. One or no oligoclonal bands in the CSF is considered normal. Follow-up of multiple myeloma, Waldenstrom macroglobulinemia, and AL amyloidosis, Immunofixation of urine and serum samples should be performed in all patients with multiple myeloma, Waldenstrom macroglobulinemia, and AL amyloidosis every 3 months after the completion of treatment in order to evaluate for response or to document a relapse. If the monoclonal protein level decreases or is undetectable after chemotherapy, it might indicate a response to treatment. A doctor may use a CSF oligoclonal banding test to help confirm a diagnosis of MS. Comparison of the Freelite serum free light chain (SFLC) assay with serum and urine electrophoresis/immunofixation and the N Latex FLC assay. oligoclonal bands: Immunoglobulins found in the cerebrospinal fluid of patients with multiple sclerosis (MS) and, occasionally, in other neurological conditions. [14], Mass spectrometry is sometimes employed in place of immunofixation because of the latters limitations, such as in the detection of low-level disease. How is a urine sample collected for an immunofixation test? Most of the clinical interest in CSF electrophoresis is focused on the region. 2005 - 2023 WebMD LLC. Healthline Media does not provide medical advice, diagnosis, or treatment. Cerebrospinal fluid oligoclonal bands in the diagnosis of multiple sclerosis. Management of clinically and radiologically isolated syndromes suggestive of multiple sclerosis. Some of the risks for spinal taps include: To minimize the risk of negative reactions, be sure to follow your doctors advice on fluids and foods, and inform them of any allergies to medications., In order to perform the CSF Oligoclonal Banding test, a sample of your cerebrospinal fluid is retrieved. The presence of these immunoglobulins can indicate inflammation in the central nervous. A doctor may use a CSF oligoclonal banding test to help confirm MS, but they will also need to consider other diagnostic criteria. Zhonghua Yi Xue Za Zhi (Taipei). [1] Serum or urine immunofixation negative for a monoclonal protein or a polyclonal pattern is considered to be normal. Why is csf protein elevated in gbs? - qyvxl.dixiesewing.com If your work is strenuous and might involve your back, tell your doctor. IgG profiles in serum and CSF are visually compared allowing the identification of oligoclonal bands originating from the intrathecal synthesis of immunoglobulins. The presence of OCBs in the CSF is an important factor in diagnosing MS. They are used in the diagnosis of various neurological and blood diseases, especially in multiple sclerosis . It causes periods of worsening symptoms and periods of remission. In most cases in which a monoclonal protein is present, it shows as a narrow band at the IgG lane in combination with a monoclonal band at the kappa or lambda lane. Oligoclonal Banding, Serum and Spinal Fluid - Bassett Healthcare Oligoclonal bands (OCBs) are a type of protein that occurs in the cerebrospinal fluid (CSF). For patients with MGUS and high risk for progression to multiple myeloma, surveillance should be performed at 6 months and then yearly thereafter. MS Brain Fog? We avoid using tertiary references. Get a step-by-step look, CSF cell count and differential are measured during cerebrospinal fluid analysis. In: Burtis CA, Bruns DE, eds. Oligoclonal band investigations requires both serum and cerebral spinal fluid (CSF). It means that the immunoglobulins are being produced in your CNS. Oligoclonal bands can be found in serum in a number of infections (e.g HIV, EBV) and autoimmune diseases. [9], Surveillance among patients with MGUS or smoldering (asymptomatic) multiple myeloma, Immunofixation of the urine and serum should be included in a battery of tests after 2-3 months following diagnosis of smoldering myeloma, then every 4-6 months for 1 year, and, finally, every 6-12 months if the results are stable. Bethesda, MD 20894, Web Policies The diagnosis of multiple sclerosis (MS) is dependent on clinical, radiological, and laboratory findings. B. Oligoclonal bands in multiple sclerosis cerebrospinal fluid: An update Medscape Education, encoded search term (Immunofixation) and Immunofixation, Fast Five Quiz: Multiple Myeloma Management, Emerging Interventions for Relapsed/Refractory Multiple Myeloma, Fast Five Quiz: Key Aspects of Multiple Myeloma, Highlights in Multiple Myeloma From ASH 2022, Use of Clinical Decision Support to Improve the Laboratory Evaluation of Monoclonal Gammopathies, FDA Calls for Withdrawal of Multiple Myeloma Drug Pepaxto. The test requires both CSF and serum samples. This is particularly true if they dont find similar bands in your blood. An official website of the United States government. The monoclonal band of immunoglobulin indicates a neoplastic process like multiple myeloma and Waldenstrom's macroglobulinemia. Clin Chem. This article reviews all you need to, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We herein review central and peripheral nervous system conditions associated with OCBs and discuss their relation with pathogenetic mechanisms. Increased intrathecal Ig synthesis may occur in other inflammatory CSF diseases and, therefore this assay is not specific for MS. Oligoclonal bands and antibody responses in multiple sclerosis, The frequency of CSF oligoclonal banding in multiple sclerosis increases with latitude, Diagnostic Tests for Neurological Disorders, Cerebrospinal fluid in multiple sclerosis, Tests for Brain, Spinal Cord, and Nerve Disorders, A Manual of Laboratory and Diagnostic Tests, Preventing Deaths from Cryptococcal Meningitis, Subacute Sclerosing Panencephalitis Information Page, Stiffness and muscle spasms that may occur in any limb but are more common in the legs. Ask your health query from live doctors now! 2018 Jun 27;56(7):1071-1080, 5. The speed of movement is dictated by their charge. Abstracts of Presentations at the Association of Clinical Scientists 143. disease who have positive oligoclonal bands have a higher risk of evolution to MS . The identification of a monoclonal immunoglobulin is helpful in the diagnosis of the following conditions Oligoclonal bands CSF and Serum - myUpchar Sample: Serum (whole blood or plasma is inappropriate, as fibrinogen may alter the results), Sample: 24-hour urine collection, concentrated. The procedure can vary depending on the doctors practices and the persons health status. These bands in the CSF pattern are produced by a limited number of immunocompetent cell clones, each producing IgG with its own specificity. Some doctors may perform a lumbar puncture using medical imaging for guidance, such as an ultrasound or interventional radiology. All Rights Reserved. Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics. [9], In addition, immunofixation can be used to monitor therapy in plasma cell dyscrasias (ie, multiple myeloma and Waldenstrom macroglobulinemia). Ann Clin Lab Sci. and transmitted securely. Medscape Drugs & Diseases. Epub 2021 Aug 13. Both serum and spinal fluid are required. (Keir G, Luxton RW, Thompson EJ: Isoelectric focusing of cerebrospinal fluid immunoglobulins G: an annotated update. Oligoclonal Banding, Serum and Spinal Fluid Useful For Diagnosis of multiple sclerosis; especially useful in patients with equivocal clinical presentation and radiological findings Profile Information Method Name Isoelectric Focusing (IEF) with IgG Immunoblot Detection NY State Available Yes Reporting Name Oligoclonal Banding Other reasons your physician may request a CSF oligoclonal banding test are to identify if other serious illnesses are present, such as: A spinal tap can pose a couple of moderate to low risks. After the test, you may notice a bruise at the needle insertion site - it will subside on its own in a few days. HHS Vulnerability Disclosure, Help A normal result is no bands or just one band. Unauthorized use of these marks is strictly prohibited. Yang G, Geng C, Chen W. Clinical characteristics of a group of patients with multiple myeloma who had two different light chains by immunofixation electrophoresis: A retrospective study from a single center. [QxMD MEDLINE Link]. [18, 19], Detection of a paraprotein by immunofixation is possible in lymphomas. We avoid using tertiary references. Can you have oligoclonal bands and not have MS? Therefore, such an approach cannot be currently recommended. CSF is used in the diagnosis of multiple sclerosis (MS) by identifying increased intrathecal IgG synthesis qualitatively (oligoclonal bands). Northwestern University researchers think so. John C Leighton, Jr, MD, FACP is a member of the following medical societies: American College of Physicians, American Medical Association, American Society of Hematology, American Society of Clinical OncologyDisclosure: Nothing to disclose. Careers. 2021 Sep;41(9):775-784. doi: 10.1007/s40261-021-01071-0. The word oligoclonal band comes from the fact that the immunoglobulins appear as separate bands when the CSF is put in a gel plate under the effect of an electric current. Blood. OLIGS - Overview: Oligoclonal Banding, Serum Monoclonal gammopathy of undetermined significance. 1. 24:1121-7. During the procedure, an anesthesiologist will withdraw your spinal fluid by inserting a thin, long needle into your spine above your pelvis. 1980 Sep;8(3):241-7 Sasson SC, McGill K, Wienholt L, Carr A, Brown DA, Kelleher AD, et al. The above information is provided from a purely educational point of view and is in no way a substitute for medical advice by a qualified doctor. CSF is used in the diagnosis of multiple sclerosis (MS) by identifying increased intrathecal IgG synthesis qualitatively (oligoclonal bands). Am J Clin Pathol. 2022;109:129-163. doi: 10.1016/bs.acc.2022.03.004. The CSF oligoclonal band screen looks for these bands in your CSF. Cavuoti D, Baskin L, Jialal I. Finally, the sample is washed to remove the proteins that do not precipitate and then stained, destained, and dried. sharing sensitive information, make sure youre on a federal 2015 Aug 26. Saadeh R, Pittock S, Bryant S, et al: CSF kappa free light chains as a potential quantitative alternative to oligoclonal bands in multiple sclerosis. The presence of these bands implies inflammation in the central nervous system (CNS) which may be caused by an infection or a disease. 2003 Nov:120(5):672-675, 3. Acta Neurol Scand. Surveillance for multiple myeloma in patients with MGUS and favorable prognostic factors (ie, low levels of monoclonal protein and IgG type) should include monitoring at 6 months and then every 2-3 years thereafter. Let your doctor know if it doesnt. doi: 10.1371/journal.pone.0186842. CSF immunofixation that does not reveal oligoclonal bands is also considered normal. On the left a serum protein electrophoresis (SPEP) of a patient with a monoclonal band in the gamma region is shown. 1993 Jan;56(1):32-5. doi: 10.1136/jnnp.56.1.32. Youll need to change into a hospital gown with the back open. Serum electrophoresis separates proteins into 5 different bands: Albumin, and Prealbumin. What conditions show oligoclonal bands in CSF? - Studybuff Once the sample is retrieved, it is analyzed in a medical laboratory., Normal results are reported when no immunoglobulin proteins, called oligoclonal bands, are found in your cerebrospinal fluid.. However, there are other possible causes of elevated OCB levels. 2019 Jan. [QxMD MEDLINE Link]. The presence of oligoclonal bands (OCBs) of immunoglobulin G (IgG) in CSF provides evidence for the occurrence of a humoral immune response, but it is not always appreciated that the oligoclonal IgG may have originated in the serum. [Full Text]. Share cases and questions with Physicians on Medscape consult. Gurtner KM, Shosha E, Bryant SC, Andreguetto BD, Murray DL, Pittock SJ, Willrich MAV. Simonsen CS, Flemmen H, Lauritzen T, Berg-Hansen P, Moen SM, Celius EG. [20]. The Consortium of Multiple Sclerosis Centers has endorsed IEF because of its increased sensitivity (>95%). The procedure usually takes about half an hour. 7th ed. How the Test is Performed A sample of CSF is needed. CSF is the clear fluid that is present around the spinal cord and the brain. Isoelectric focusing with the IgG immunoblotting compared with high resolution agarose gel electrophoresis and cerebrospinal fluid IgG index. If similar. This helps the doctor insert the needle more easily. Collection in a container: A plastic collection container is used. You may need to arrange to take the day of your test off. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. -, N Engl J Med. Long-lasting double vision Slurred speech Bowel or bladder problems Dizziness Fatigue Other reasons your physician may request a CSF oligoclonal banding test are to identify if other serious. Morris C, Drake M, Apperley J, et al. Oligoclonal Band - an overview | ScienceDirect Topics This pattern represents the presence of polyclonal immunoglobulin. Differentiating patterns of oligoclonal banding in the cerebrospinal fluid improves diagnostic utility for multiple sclerosis. Fortini AS, Sanders EL, Weinshenker BG, Katzmann JA: Cerebrospinal fluid oligoclonal bands in the diagnosis of multiple sclerosis. 2011. 2018 Sep 7. In Goldman L, Schafer AI, eds. The significance of serum oligoclonal bands in neurological diseases. The oligoclonal band pattern is blurred when a concomitant inflammatory response causes increased protein leakage of plasma proteins into the CSF. 2019 May 23. Can poor sleep impact your weight loss goals? But it can also be used to treat disorders that cause overactive muscles or pain. 2005-2023 Healthline Media a Red Ventures Company. Detection of Oligoclonal Ig Bands: Clinical Significance and Trends in Methodological Improvement. In order to confirm local production of oligoclonal IgG in CSF, a matched serum sample is required. They will remove the needle and apply a dressing. This test is not specific for multiple sclerosis. CSF Oligoclonal Bands Interpretation: <2 bands, mml-Behavioral, mml-Epilepsy, mml-Movement-Disorders, mml-Demyelinating-Diseases, mml-Neuroimmunology, mml-Neuromuscular, mml-Autonomic, mml-Neuro-oncology, mml-Pediatric, mml-Pain, mml-Spinal-Cord, mml-Neuro-ophthalmology. [2] : Monoclonal gammopathy of undetermined significance (MGUS) However, most patients with a monoclonal protein will be finally diagnosed with MGUS rather than any of the malignant plasma cell dyscrasias for which treatment is recommended. A person does not need to do much to prepare for the test itself. The results of an EEG can be used to rule out or confirm. During the procedure, a person will lie on their side with their legs pulled up toward their chin and their chin tucked in. Saint Luke's Regional Laboratories began using this method in September 2003. When abnormal results are reported back to your physician, further medical investigations can pursue the cause for the increased presence of immunoglobulin proteins in your cerebrospinal fluid. A. [Full Text]. According to a 2019 study, a lack of OCBs in those who present with MS-like symptoms may indicate that another underlying condition is present, such as migraine. Multiple sclerosis and systemic sclerosis are two autoimmune conditions that affect different parts of the body. Spinal fluid must be obtained within 7 days of serum collection. They are used as a marker of MS when magnetic resonance imaging studies of the brain are not diagnostic. Oligoclonal Band Test is intended for identifying oligoclonal banding in paired serum and cerebrospinal fluid (CSF) using isoelectric focusing and immunoblotting. The significance of serum oligoclonal bands in neurological diseases Centers for Disease Control and Prevention: Systemic Lupus Erythematosus (SLE)., Cerebrospinal Fluid Research: The regulation of brain states by neuroactive substances distributed via the cerebrospinal fluid; a review., Cleveland Clinic: Cerebrospinal Fluid (CSF) Leak., HHS Author Manuscripts: Central Nervous System Agents for Ischemic Stroke: Neuroprotection Mechanisms., JAMA Neurology: Oligoclonal Band Number as a Marker for Prognosis in Multiple Sclerosis., Johns Hopkins Medicine: Neurological Complications of HIV., Mayo Clinic: Multiple sclerosis., Oligoclonal Banding, Serum and Spinal Fluid., Multiple Sclerosis Trust: Lumbar puncture., National Multiple Sclerosis Society: Cerebrospinal Fluid (CSF)., New Medical Life Sciences: What is the Nervous System?, University of California San Francisco Health: Medical Tests CSF oligoclonal banding.. Again, the lanes are broad and the transition to the lane borders is smooth. Your spinal cord and your brain make up your nervous system.. A local anaesthetic is used for the short procedure. [7], The identification of oligoclonal bands in CSF is helpful in the diagnosis of multiple sclerosis. Seiter K, Ponce D. Waldenstrom macroglobulinemia. Exp Ther Med. 147:22-42. Bands found in both serum and CSF indicate a generalised infection, sarcoidosis (an inflammatory disease affecting many organs), neoplasia or an autoimmune disorder (a condition where the immune system damages normal body tissue). If similar bands aren't present in your blood, you may have multiple sclerosis (MS). Mass spectrometry for the evaluation of monoclonal proteins in multiple myeloma and related disorders: an International Myeloma Working Group Mass Spectrometry Committee Report. Ann Clin Biochem 1990;27:436-443; Hortin GL: Amino Acids, Peptides, and Proteins. All rights reserved. Diagnosis of multiple sclerosis; especially useful in patients with, Clients without access to Test Prices can contact, Prospective clients should contact their account representative. Anastasios Dimou, MD Resident Physician, Department of Internal Medicine, Albert Einstein Medical CenterDisclosure: Nothing to disclose. Lumbar puncture is widely used and considered safe. Oligoclonal bands may be observed in the following conditions: Disclaimer: All results must be clinically correlated with the patients complaints to make a complete and accurate diagnosis. [11] HIV-related encephalitis, neurosyphilis, Lyme meningoencephalitis, neurosarcoidosis, acute disseminated encephalomyelitis (ADEM), systemic lupus erythematosus (SLE), Sjgren syndrome, subacute sclerosing panencephalitis, CNS malignancy, neuromyelitis optica, and transverse myelitis can all reveal oligoclonal banding in CSF immunofixation, precluding the use of immunofixation for the detection of oligoclonal bands as a sole diagnostic technique in multiple sclerosis. Their presence suggests inflammation of the central nervous system due to infection or another disease. 1987 Oct;44(10):1041-4 National Library of Medicine CSF examination showed a slightly elevated cell count of 13 cells/l and a mildly elevated protein level at 54 mg/dl (laboratory reference: 15-45 mg/dl). All Rights Reserved. StatPearls. 2011. Oligoclonal band - Wikipedia Oligoclonal Band 5th. Your doctor may order this test if he/she suspects that you have multiple sclerosis. Unconcentrated CSF and diluted serum are electrophoresed by isoelectric focusing. CSF is used in the diagnosis of multiple sclerosis (MS) by identifying increased intrathecal IgG synthesis qualitatively (oligoclonal bands). Theyll send the CSF to a laboratory for analysis. Medscape Drugs & Diseases. The CSF oligoclonal band screen looks for these bands in your CSF. A concomitant measurement of the creatinine in the 24-hour urine sample for correction of sampling errors has been proposed. what conditions show oligoclonal bands in csf and serum? Kyle RA, Durie BG, Rajkumar SV, et al. Could a little jolt of electricity to the outside of your head improve your brain function? what conditions show oligoclonal bands in csf and serum? 109:585-8. Pathology. 2022 Sep;59(6):391-404. doi: 10.1080/10408363.2022.2039591. springerlink.com/content/lv0r2xt58rj600jb/, mayoclinic.org/tests-procedures/lumbar-puncture/basics/definition/prc-20012679, mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/8017, books.google.com/books?id=FCbXDdOvB9IC&pg=PA319&lpg=PA319&dq=oligoclonal+Banding+meningitis&source=bl&ots=xXaV_Bq2ej&sig=Cf3UhU2a8sxtckVKViJkIujPHPE&hl=en&sa=X&ei=b1EEUL2GC-LC2QWx4dGqCw&ved=0CEwQ6AEwAQ#v=onepage&q=oligoclonal%20Banding%20meningitis&f=false, When Forgiveness Becomes Enough: Cindy Jenkins Talks OCD. This article discusses the link between OCBs and MS and what the testing involves. 1998. UK Myeloma Forum (UKMF) and Nordic Myeloma Study Group (NMSG): guidelines for the investigation of newly detected M-proteins and the management of monoclonal gammopathy of undetermined significance (MGUS). Arch Pathol Lab Med. An oligoclonal band is a protein called an immunoglobulin. The presence of 2 or more unique CSF oligoclonal bands was reintroduced as one . 11 (2):24. Epub 2022 Apr 22. MS is a disease that affects the CNS, which consists of the brain and spinal cord. The following steps take place during a lumber puncture: You can expect to rest for an hour or two after your test. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Wallach, J. 1. Cerebrospinal fluid (CSF) is the liquid that protects and cushions your brain and spinal cord. What conditions show oligoclonal bands in serum? What Is CSF Oligoclonal Banding? - WebMD Albumin is formed in the liver and is 60% of total proteins. However, technical issues including blot, staining, and IEF reproducibility as well as operator-dependent pattern interpretations decrease reproducibility, causing misinterpretations of results, with significant diagnostic implications. what conditions show oligoclonal bands in csf and serum? Epub 2022 Apr 22. Medscape Drugs & Diseases. 2023 Laboratory Corporation of America Holdings. The doctor or nurse will then perform the following steps: Lab technicians will then analyze the CSF sample for OCBs. [QxMD MEDLINE Link]. If they find that a person has MS, they will work with the individual to develop a treatment plan based on their particular needs. doi: 10.1136/bcr-2020-234316. Guido Tricot. CNS comprises the spinal cord and the brain. In some cases, additional time should be The oligoclonal band (OCB) assay requires paired cerebrospinal fluid (CSF) and serum samples. You are wondering about the question what conditions show oligoclonal bands in csf and serum but currently there is no answer, so let kienthuctudonghoa.com summarize and list the top articles with the question. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. SI Abnormal Reports. Diagnosis of multiple sclerosis; especially useful in patients with equivocal clinical presentation and radiological findings, Isoelectric Focusing (IEF) with IgG Immunoblot Detection. A normal result includes a darker immunoglobulin G (IgG) lane, a lighter immunoglobulin A (IgA), an absent immunoglobulin M (IgM), and a denser kappa compared to lambda lane, with ratio of 2:1. Immunofixation electrophoretic techniques applied to identification of proteins in serum and cerebrospinal fluid. Both serum and spinal fluid are required. Additionally, your symptoms could be due to injury to a nerve, pressure on spinal or peripheral nerves (neuropathy), vitamin deficiency, lack of blood supply due to cholesterol plaque from atherosclerosis in the extremities, viral infection and use of certain medications. Eric B Staros, MD is a member of the following medical societies: American Medical Association, American Society for Clinical Pathology, Association for Molecular Pathology, College of American PathologistsDisclosure: Nothing to disclose. What do Oligoclonal Bands CSF and Serum test results mean? Note: Normal value ranges may vary slightly among different laboratories. Thompson AJ, Banwell BL, Barkhof F, et al: Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Heres what you need to know about it. what conditions show oligoclonal bands in csf and serum? Symptoms of multiple sclerosis include:. Immunofluorescence analysis revealed anti-Ri antibodies in both serum and CSF (1:10,000). In particular, when serum and urine protein electrophoresis results are negative, immunofixation is indicated as a more sensitive test if the clinical suspicion remains high. The reason for this is that the presence of OCBs can also indicate other conditions that cause inflammation in the CNS. PMC Make certain to include both prescription and over-the-counter medicines. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. The presence of these immunoglobulins can indicate inflammation in the central nervous system (CNS), which can suggest that a person has multiple sclerosis (MS). WebMD does not provide medical advice, diagnosis or treatment. Oligoclonal Banding, Serum and Spinal Fluid - Neurology Catalog Oligoclonal Bands - UpToDate [QxMD MEDLINE Link]. More than 90% of patients with multiple sclerosis show oligoclonal banding at some time during the course of their disease. 2020 Jan 22;6(1):2055217319901291. doi: 10.1177/2055217319901291. Hereditary spastic paraparesis. Assessment of oligoclonal bands in cerebrospinal fluid and serum of Twenty-four-hour Bence-Jones protein determinations: can we ensure accuracy?. In addition, serum oligoclonal bands are present in some patients with Hodgkin's disease and in up to 5% of normal individuals. This should go away within 24 hours. Mayo Clinic. Saadeh R, Pittock S, Bryant S, et al: CSF kappa free light chains as a potential quantitative alternative to oligoclonal bands in multiple sclerosis. The presence of oligoclonal bands may point to a diagnosis of multiple sclerosis.
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