Digestive System Disorders. .fixedHeaderWrap { These include vascular access procedures, airway and ventilation management services, oral or nasogastric tube placement, bladder aspiration or catheterization, and lumbar puncture among others. Cochrane Database Syst Rev. ol.numberedList LI { The condition affects 3 percent of term male infants, and 1 percent of male infants at one year. Waltham, MA: UpToDate;reviewed January 2015; January 2017. 2012;12:CD009017. FN07-02. Inpatient treatment is generally not medically necessary for healthy full-term infants with aTSB less than 20 mg/dL, as these infants can usually be treated with expectant observation or home phototherapy. The receiver operating characteristic analysis (for serum bilirubin levels greater than 205.2 micromol/L or greater than 239.4 micromol/L) showed significantly higher areas under the curve for BiliCheck than those for BiliMed (p < 0.001). Depending on the study, 2 to 10 percent of newborns have inconclusive results at discharge (e.g., there may be fluid in the middle ear; the newborn may be fussy; one ear might pass, but the other does not). It is also important to note that thereare serious health risks associatedwith corticosteroid therapy. Analysis of rebound and indications for discontinuing phototherapy. PDF Pediatric Coding - AAPC Cryptorchidism Risk of bias was assessed using the QUADAS-2 tool. Primary outcome was the duration of phototherapy. } 2001;108:31-39. Inpatient treatment may be medically necessary for pre-term infants who present with a TSB greater than or equal to 18 mg/dL. Report code 99466 for 30-74 minutes of hands-on care and code 99467 for each additional 30 minutes of hands-on care. The China National Knowledge Infrastructure and MEDLINE databases were searched. The genotype of Gilbert syndrome, the UGT1A1*28 allele, causes markedly reduced activity of this enzyme, but its association with neonatal hyperbilirubinemia is uncertain and its relationship with extreme hyperbilirubinemia has not been studied. We are looking for thought leaders to contribute content to AAPCs Knowledge Center. list-style-type: upper-roman; Liu J, Long J, Zhang S, et al. 2010;47(5):401-407. Moreover, individuals carrying the A-allele of G6PD 1388 G>A and BLVRA rs699512 had a significantly increased risk of developing neonatal hyperbilirubinemia (OR=5.01, p< 0.001, 95 % CI: 3.42 to 7.85). Armanian and colleagues (2019) stated that hyperbilirubinemia occurs in approximately 2/3 of all newborns during the first days of life and is frequently treated with phototherapy. Zhang M , Tang J, He Y, et al. Ip S, Glicken S, Kulig J, et al. Therefore, well-designed, large randomized, double blind, placebo-controlled trials would be needed to further confirm the efficacy of probiotics. Report an inclusive screening finding (R94.120 Abnormal auditory function study) in the professional record so the newborn can be retested at the well-baby checks. An alternative to prolonged hospitalization of the full-term, well newborn. PDF Bilirubin Light - Phototherapy - Northwood Inc. Coding Guidelines 18, 19 The third trimester is the time of rapid weight gain, development of muscle mass and fat stores for the newborn. The AAP Guidelines suggest that an infant readmitted for hyperbilirubinemia, with a level of 18 mg/dL or more, should have a level of 13 - 14 mg/dL in order to discontinue phototherapy. A total of 150 term Caucasian neonates, 255 measurements of TSB and TcB concentration were obtained 2 hours after discontinuing phototherapy. De Luca D, Zecca E, Corsello M, et al. Seidman DS, Stevenson DK, Ergaz Z, et al. 2003;88(6):F459-F463. J Perinatol. J Perinatol. Hulzebos CV, Bos AF, Anttila E, et al. In utero, the fetus requires larger amounts of hemoglobin for oxygenation. Data sources included PubMed, Embase, Cochrane library, China National Knowledge Infrastructure, China Biology Medicine, VIP Database, and Wanfang Database. Pediatrics. 1992;89:823-824. J Matern Fetal Neonatal Med. Porter ML, Dennis BL. The authors concluded that phototherapy significantly interfered with the accuracy of transcutaneous bilirubinometry; TcB measurements performed 2 hours after stopping phototherapy were not reliable, even if they were performed on the unexposed body area. Semin Fetal Neonatal Med. This is not a reportable inpatient condition. Aggressive phototherapy did reduce rates of neurodevelopmental impairment (26 %, versus 30 %for conservative phototherapy; relative risk, 0.86; 95 % CI: 0.74 to 0.99). PDF ACDIS day3-5 track5-9 pres 0517-Rogers-f A fetus blood is different than an adults. Analysis was performed on an intention-to-treat basis. The authors concluded that effects of screening on the rates of bilirubin encephalopathy are unknown. The following are general age-in-hours specifictotal serum bilirubin (TSB)threshold values for phototherapy based upon gestational age and the presence or absence of risk factors (isoimmune hemolytic disease, glucose-6-phosphate dehydrogenase [G6PD] deficiency, asphyxia, significant lethargy, temperature instability, sepsis, acidosis, or albumin of less than 3.0 g/dL [if measured]): Footnotes* Low Risk: 38 weeks gestation and without risk factors; Medium Risk: 38 weeks gestation with risk factors or 35 to 37 6/7 weeks gestation without risk factors; High Risk: 35 to 37 6/7 weeks gestation with risk factors. No association was found between the UGT1A1*28 allele and extreme hyperbilirubinemia. Although an undescended testicle usually is described as palpable or impalpable, also get the location, if you can. These researchers conducted a systematic review of studies comparing TcB devices with TSB in infants receiving phototherapy or in the post-phototherapy phase. If your newborn is too warm, remove the curtains or cover from around the light set. Usually, clicking hips lead to no findings but are noted so other providers know there is not issue. If this is your first visit, be sure to check out the. I have a provider that ordered phototherapy for a newborn in the hospital with jaundice and he is wanting to bill 96900. The authors concluded that in this study population, GS polymorphism alone did not appear to play a major role in severe neonatal hyperbilirubinemia in neonates without signs of hemolysis. Gu J, Zhu Y, Zhao J. Compared with hospital-based phototherapy, home-based phototherapy appeared more effective for the treatment of neonatal hyperbilirubinemia in reducing the rate of total serum bilirubin (standard mean difference [SMD] = 0.32, 95 % CI: -0.22 to 0.86, p = 0.04); however, there was no signicant difference in duration of phototherapy (SMD = 0.59, 95 % CI: 0.28 to 0.90, p = 0.06) in the 2 groups. Merenstein GB. color: blue!important; Starting Feb. 1, 2022, five new CPT codes will require preauthorization. Am Fam Physician. The G6PD 1388 G>A, SLCO1B1 rs4149056 and BLVRA rs699512 SNPs had a significant impact on STB levels. This Clinical Policy Bulletin contains only a partial, general description of plan or program benefits and does not constitute a contract. TcB should not be used in patients undergoing phototherapy.". The authors concluded that genetic variants of bilirubin metabolism genes, including G6PD 1388 G>A, SLCO1B1 rs4149056 and BLVRA rs699512, were associated with the risk of neonatal hyperbilirubinemia, and are potential markers for predicting the disorder. However, only 1 trial (out of 2) reported significant reduction in bilirubin levels in preterm neonates. Cochrane Database Syst Rev. OL OL OL OL OL LI { Support Lucile Packard Children's Hospital Stanford and child and maternal health, AAP Clinical Practice Guideline -- Full Version, Assessing Risk Based on Bilirubin Level -- "BiliTool", Infants who have not latched-on or nursed effectively for 12 hours, Infants supplemented more than once in 24 hours, Mothers with a history of breastfeeding failure, Antepartum mothers at risk of preterm delivery, AAP Clinical Practice Guideline - Summary. Stigma (plural stigmata) is a finding that may indicate an abnormal condition, such as a sacral dimple without a visible floor being stigma for occult spina bifida. 4th ed. 2017;30(16):1953-1962. Bhutani VK, Stark AR, Lazzeroni LC, et al; Initial Clinical Testing Evaluation and Risk Assessment for Universal Screening for Hyperbilirubinemia Study Group. Neonatal Hyperbilirubinemia - Medical Clinical Policy Bulletins | Aetna Aggressive phototherapy, as compared with conservative phototherapy, significantly reduced the mean peak serum bilirubin level (7.0 versus 9.8 mg/dL [120 versus 168 micromol/L], p < 0.01) but not the rate of the primary outcome (52 % versus 55 %; relative risk, 0.94; 95 % confidence interval [CI]: 0.87 to 1.02; p = 0.15). PubMed, Embase, Web of science, EBSCO, Cochrane library databases, Ovid, BMJ database, and CINAHL were systematically searched; RCTs evaluating the effect of zinc sulfate versus placebo on the prevention of jaundice in neonates were included. These researchers stated that healthcare organizations and health workers should choose intermittent phototherapy as the preferred therapy for neonatal hyperbilirubinemia. None of the studies showed any effect on the duration of phototherapy, incidence of phototherapy, age of starting of phototherapy and any serious adverse effect. Home Phototherapy for Neonatal Jaundice (07.06.02) COVERED: ACCORDING TO CERTAIN CRITERIA Phototherapy is often used to treat neonatal jaundice and involves the continuous application of ultraviolet light via a lamp or a beroptic system to a newborn for a prescribed period of time. Family physicians who perform newborn circumcision should separately report this service. 1992;89:822-823. Saunders Co.; 2000:513-519. Prediction of hyperbilirubinemia in near-term and term infants. Acta Paediatr. Two reviewers independently assessed studies for inclusion, and discrepancies were resolved with consensus. The presumed mechanism of effect is photo-excitation of bilirubin extravascularly in the skin with the formation of bilirubin isomers which can be e 2016;109(3):203-212. The total number of neonates enrolled in these different RCT were 749. Documentation should include approximate time spent face-to-face with the family and patient, notation of time spent in counseling, and context of counseling. Evaluation and management (E/M) services provided to normal newborns in the first days of life prior to hospital discharge are reported with Newborn Care Services codes. These researchers identified studies through Medline searches, perusing reference lists and by consulting with United States Preventive Services Task Force(USPSTF) lead experts. Overall, compared with placebo, zinc sulfate supplementation failed to significantly reduce TSB on 3 days (MD=0.09mg/dL; 95 % CI:-0.49 to 0.67; p=0.77), TSB on 7 days (MD=-0.37mg/dL; 95 % CI:-98 to 0.25; p=0.25) as well as the incidence of hyperbilirubinemia (OR=1.14; 95 % CI:0.74 to 1.76; p=0.56). 1992;31(6):345-352. cpt code for phototherapy of newbornhippo attacks human video. Utilization Mangement and Q uality Review Manual Nebraska M edicaid, 2014, Phototherapy equipment (471 N AC 18-004.45A) Torres-Torres M, Tayaba R, Weintraub A, et al. J Pediatr Health Care. Arch Dis Child Fetal Neonatal Ed. 2021;77(1):12-22. Morris and colleagues (2008) compared aggressive versus conservative phototherapy for infants with extremely low birth weight. Indian Pediatr. 6A650ZZ - Phototherapy, Circulatory, Single Version 2023 Billable Code ICD-10-PCS Details 6A650ZZ is a billable procedure code used to specify the performance of phototherapy, circulatory, single. This is caused by a small opening in the abdominal muscles that abdominal contents (e.g., fluid, abdominal lining) spill through. 2003;(1):CD004207. Accessed January 30, 2019 . This is usually associated with one of the codes from Q65 Congenital deformities of the hip. Bilirubin recommendations present problems: New guidelines simplistic and untested. Reference No. Clin Pediatr (Phila). The USPSTF and the Agency for Healthcare Research and Quality (2009) reported on the effectiveness of various screening strategies for preventing the development of CBE. Stevenson DK, Fanaroff AA, Maisels MJ, et al. For more information about blocked lacrimal ducts, visit: aao.org/eye-health/diseases/treatment-blocked-tear-duct. If done right, you will hear a popping sound. Randomized and quasi-randomized controlled trials of pregnant women established to have red cell isoimmunization in the current pregnancy during their antenatal testing and given phenobarbital alone or in combination with other drugs before birth were selected for review. Moreover, they stated that routine use of probiotics to prevent or treat neonatal jaundice cannot be recommended; large well-designed trials are needed to confirm these findings. .strikeThrough { Centers for Disease Control and Prevention (CDC). Long-term follow-up studies reported an increased risk of abnormal neurological examination and cerebral palsy. Menu penelope loyalty quotes. During an initial newborn evaluation, watchful waiting conditions are findings that usually resolve without medical intervention in a few weeks to a few years. They stated that further research is needed before the use of TcB devices can be recommended for these settings. cpt code for phototherapy of newborn - colspiritlifecoaching.com The infant is otherwise ready to be discharged from the hospital; The infant is feeding well, is active, appears well; TSBis less than 20 to 22 mg/dL in term infants, or less than 18 mg/dL in preterm infants; Arrangements have been made to evaluate the infant within 48 hours after discharge by an early office/clinic visit to the pediatrician, or by a home visit by a well-trained home health care nurse who should be able to: Be available for follow-up clinical assessments and blood drawing as determined to be necessary by the responsible physician based on changes in bilirubin levels, Clinically assess the initial level of jaundice, Explain all aspects of the phototherapy system to the parents, Oversee set-up of the phototherapy system. } A systematic evidence review prepared for the Cochrane Collaboration (Suresh et al, 2003) concluded that, based upon limitations of the evidence, "[r]outine treatment of neonatal unconjugated hyperbilirubinemia with a metalloporphyrin cannot be recommended at present.". .newText { [Phototherapy of newborn infants] - PubMed After maintenance phototherapy was discontinued, 7 patients (23% ) had a sustained disease-free interval lasting more than 58 months (median of greater than 90 months). Kernicterus in full-term infants--United States, 1994-1998. herman's coleslaw recipe. The literature search was done for various randomized control trial (RCT) by searching the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, Embase, Web of Science, Scopus, Index Copernicus, African Index Medicus (AIM), Thomson Reuters (ESCI), Chemical Abstracts Service (CAS) and other data base. You are using an out of date browser. Report an inclusive screening finding (R94.120 Abnormal auditory function study) in the professional record so the newborn can be retested at the well-baby checks. Pediatrics. Suresh GK, Martin CL, Soll RF. Zinc sulfate showed no influence on phototherapy requirement (OR=0.90; 95 % CI:0.41 to 1.98; p=0.79), but resulted in significantly decreased duration of phototherapy (MD=-16.69hours; 95 % CI:-25.09 to -8.3hours; p<0.0001). Involve significant costs (e.g., use of the operating room, more expensive diagnostic imaging types, such as computed tomography and magnetic resonance imaging); Are risky (e.g., bedside spinal taps, epidural/regional/general anesthesia); Milia (including Bohn nodules on the gum and Epstein pearls on the palate). Meta-analysis (random-effects model) showed probiotic supplementation reduced duration of phototherapy [n=415, MD: -11.80 (-17.47 to -6.13); p<0.0001; level of evidence (LOE): low]; TSB was significantly reduced at 96hours [MD: -1.74 (-2.92 to -0.57); p=0.004] and 7 days [MD: -1.71 (-2.25 to -1.17); p<0.00001; LOE: low] after probiotic treatment. 1990;10(4):435-438. Pediatrics. cpt code for phototherapy of newborn. Newborn jaundice happens when the newborns liver and sunshine on the newborns skin dont remove the fetal blood components in an efficient manner. Practice patterns in neonatal hyperbilirubinemia. Moreover, they stated that as the quality of included studies and the limitations of samples, the long-term safety and efficacy still need to be confirmed by long-term and high-quality research. Gholitabar M, McGuire H, Rennie J, et al. Incidence of hyperbilirubinaemia, defined as serum total bilirubin (STB) greater than or equal to 15 mg/dL, was similar between groups (n = 286; risk ratio (RR) 0.94, 95 % CI: 0.58 to 1.52). These usually heal and resolve on their own. Treating providers are solely responsible for medical advice and treatment of members. /* aetna.com standards styles for templates */ Pediatrics. } The correlation coefficient improved marginally in the post-phototherapy phase (r = 0.72, 95 % CI: 0.64 to 0.78, 4 studies). MMWR Morb Mortal Wkly Rep. 2001;50(23):491-494. Phototherapy in the home setting. list-style-type: decimal; 2011;128(4):e1046-e1052. foam closure strips for metal roofing | keokuk, iowa arrests newington high school football coach 0 Studies were analyzed for methodological quality in a "Risk of bias" table. Guidelines for Perinatal Care. Trikalinos TA, Chung M, Lau J, Ip S. Systematic review of screening for bilirubin encephalopathy in neonates. Ludwig MA. cpt code for phototherapy of newborn - smujsuperfoods.com The ICD-10-PCS code for light treatment of the skin is 6A600ZZ Phototherapy of skin, single for a single treatment. list-style-type : square !important; Sometimes, a newborns clavicle is fractured during a vaginal delivery. The drug was administered into the mouth of the infant by the plastic measure provided with the bottle or with a spoon. They used a fixed-effect method in combining the effects of studies that were sufficiently similar; and then used the GRADE approach to assess the quality of the evidence. The literature search was done for various RCTs by searching the Cochrane Library, PubMed, and Embase. These researchers systematically evaluated the safety and efficacy of probiotics supplement therapy for pathological neonatal jaundice. Use total bilirubin. Otherwise healthy newborn infants with hyperbilirubinemia without signs of hemolytic disease; gestational age 33 weeks; birth weight . There was diagnostic testing or a specialty inpatient consult; or. Normal newborn care services are reported with these codes: 99460 Initial hospital or birthing center care, per day, for E/M of normal newborn infant 99462 Subsequent hospital care, per day, for E/M of normal newborn The Coding for Pediatrics manual defines a normal newborn as the following: Transitions to life in the usual manner. When the pediatrician spends additional time explaining the skin condition, and the findings affect the episode of care, it should be coded on professional encounters. --> J Matern Fetal Neonatal Med. Because this is a normal condition, there is no code for it. Third, since RCTs of included studies centered in a short observation period and did not follow-up the patients in long-term, the methodological quality of clinical trials with probiotics supplementation therapy for neonatal jaundice needed further improvement. The ball at the proximal end of the femur is supposed to fit snuggly into the acetabulum (the cup-shaped depression in the pelvis). cpt code for phototherapy of newborn - s227879.gridserver.com Do not report Q10.3 Q10.6 or any of the H04 Disorders of lacrimal system for immaturity of the lacrimal ducts. American Academy of Pediatrics Subcommittee on Hyperbilirubinemia. Newman TB, Maisels MJ. The authors concluded that there are insufficient data from different countries on the use of clofibrate in combination with phototherapy for hyperbilirubinemia to make recommendations for practice. They used the standard search strategy of Cochrane Neonatal to search the Cochrane Central Register of Controlled Trials (CENTRAL 2018, Issue 5), Medline via PubMed (1966 to June 14, 2018), Embase (1980 to June 14, 2018), and CINAHL (1982 to June 14, 2018). Hyperbilirubinemia in the term newborn. Evaluation and treatment of jaundice in the term infant: A kinder, gentler approach. In a Cochrane review, Mishra and colleagues (2015) examined the effect of oral zinc supplementation compared to placebo or no treatment on the incidence of hyperbilirubinaemia in neonates during the first week of life and to evaluate the safety of oral zinc in enrolled neonates. Chu L, Qiao J, Xu C, et al. } 66940 Removal of lens material; extracapsular (other than 66840, 66850, 66852) Learn more about pediatric cataract billing in Ophthalmic Coding: Learn to Code . Serum and transcutaneous bilirubin (TcB) measurements were taken with both devices within 15 mins. Exploring the genetic architecture of neonatal hyperbilirubinemia. PDF CP.MP.150 Phototherapy for Neonatal Hyperbilirubinemia - Health Net Oregon www.hayesinc.com. For instance, abnormal findings on screenings for example, newborn hearing screening or lab screenings are not coded in the inpatient record, unless: Here are several watchful waiting findings to consider. phototherapy | Medical Billing and Coding Forum - AAPC Pediatrics. As a family physician, you may also address needs of the mother during a newborn's encounter (e.g., lactation problems). padding: 10px; Gartner LM, Gartner LM,. #closethis { There were no probiotic-related adverse effects. cursor: pointer; 2010;(1):CD001146. The impact of SLCO1B1 genetic polymorphisms on neonatal hyperbilirubinemia: A systematic review with meta-analysis. color: red color: red!important; Results were summarized as per GRADE guidelines. Guidelines from the AAP stated: "There is now evidence that hyperbilirubinemia can be effectively prevented or treated with tin-mesoporphyrin, a drug that inhibits the production of heme oxygenase. Predischarge screening for severe neonatal hyperbilirubinemia identifies infants who need phototherapy. However, if significant time beyond that typical of the infant preventive service is spent in counseling, physicians may also report a problem-oriented service (99212-99215) with modifier -25 to indicate the significant and separately identifiable services provided on the same date. Extreme neonatal hyperbilirubinemia and a specific genotype: A population-based case-control study. Treatment effects on the following outcomes were determined: mean change in bilirubin levels, mean duration of treatment with phototherapy, number of exchange transfusions needed, adverse effects of clofibrate, bilirubin encephalopathy and neonatal mortality. As with the initial critical care, only one physician may report code 99469 on a given date. Early corticosteroid treatment does not affect severity of unconjugated hyperbilirubinemia in extreme low birth weight preterm infants. Chawla D, Parmar V. Phenobarbitone for prevention and treatment of unconjugated hyperbilirubinemia in preterm neonates: A systematic review and meta-analysis. Intensive phototherapy in form of double light is used worldwide in the treatment of severe neonatal hyperbilirubinemia. UpToDate [online serial]. Clinical Policy Bulletins are developed by Aetna to assist in administering plan benefits and constitute neither offers of coverage nor medical advice. A total of 25 infants had been randomized into the DXM group; 29 into the placebo group. American Academy of Pediatrics and American College of Obstetricians and Gynecologist. Screening is usually done as close as possible to inpatient discharge for this reason. Our providers amend their office note to indicate the patient was admitted due to results then charge an Initial Outpatient Care code (99218-99220) for the day of admission and then 99217 for discharge. A total of 13 RCTs involving 1,067 neonatal with jaundice were included in the meta-analysis. Guidelines from the American Academy of Pediatrics (AAP, 2004)on management of hyperbilirubinemia in thenewborn infantstate that "Measurement of the glucose-6-phosphate dehydrogenase (G6PD) level is recommended for a jaundiced infant who is receiving phototherapy and whose family history or ethnic or geographic origin suggest the likelihood of G6PD deficiency or for an infant in whom the response to phototherapy is poor(evidence quality C: benefits exceed harms)". In some cases, phototherapy will only be needed for 24 hours or less, in some cases, it may be required for 5 to 7 days. The lining of the abdomen pouches into the scrotum to surround the testicle. Various trials in pregnant women who were not isoimmunized but had other risk factors for neonatal jaundice have shown a reduction in need for phototherapy and exchange transfusion by the use of antenatal phenobarbital. Lacrimal ducts are the drainage system for fluid that lubricates the eye. 92586 Auditory evoked potentials for evoked response audiometry and/or testing of the central nervous system, limited Semin Fetal Neonatal Med. 2002;65(4):599-606. 16th ed. Usually, procedures coded: Low-cost, low-risk screening and prevention procedures usually are not coded. Chu L, Xue X, Qiao J. Efficacy of intermittent phototherapy versus continuous phototherapy for treatment of neonatal hyperbilirubinaemia: A systematic review and meta-analysis. Secondary outcomes included incidence of jaundice, TSB level at 24, 48, 72, 96hours, and day 7, duration of hospital stay, and adverse effects (e.g., probiotic sepsis). Usually, the nurses pin the sleeve of the affected arm to the body of the newborns t-shirt. Mean STB levels, mg/dL, at 72 12 hours were comparable in both the groups (n = 286; mean difference (MD) -0.20; 95 % CI: -1.03 to 0.63). These investigators included trials where neonates with hyperbilirubinemia received either clofibrate in combination with phototherapy or phototherapy alone or placebo in combination with phototherapy. Nelson Textbook of Pediatrics. Aetna considers the use of metalloporphyrins (e.g., stannsoporfin (tin mesoporphyrin), Stanate, WellSpring Pharmaceutical Corporation, Neptune, NJ) for the treatment of neonatal jaundice experimental and investigational because their safety and effectiveness for this indication has not been established. cpt code for phototherapy of newborn - mycyberplug.com J Pediatr Gastroenterol Nutr. However, the accuracy of TcB devices in infants exposed to phototherapy is unclear. 2013;162(3):477-482. Stevenson DK, Fanaroff AA, Maisels MJ, et al. text-decoration: line-through; Cochrane Database Syst Rev. High Intensity Phototherapy: Double vs. Single - Home - ClinicalTrials.gov Data selection and extraction were performed independently by 2 reviewers. Databases including PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wan Fang Database (Wan Fang), Chinese Biomedical Literature Database (CBM), VIP Database for Chinese Technical Periodicals (VIP) were searched and the deadline was December 2016; RCTs of probiotics supplementation for pathological neonatal jaundice in publications were extracted by 2 reviewers. Evans D. Neonatal jaundice. Maisels MJ, Kring E. Length of stay, jaundice, and hospital readmission. J Pediatr. It may not display this or other websites correctly. Some watchful waiting issues require continued outpatient evaluation until resolution. Some studies showed that unclear random allocation and allocation plan might exaggerate the hidden effect of up to 30 to 41 %. Genotypes were obtained through the Danish Neonatal Screening Biobank. There were no reports of the need for exchange transfusion and incidence of acute bilirubin encephalopathy, chronic bilirubin encephalopathy, and major neurodevelopmental disability in the included studies. Dennery PA. Metalloporphyrins for the treatment of neonatal jaundice. These services include intensive cardiac and respiratory monitoring, continuous and/or frequent vital sign monitoring, heat maintenance, enteral and/or parenteral nutritional adjustments, laboratory and oxygen monitoring, and constant observation by the health care team under direct physician supervision.